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. 2022 Mar 31;13:830396. doi: 10.3389/fimmu.2022.830396

Figure 1.

Figure 1

Distribution and relationship of g-NK and NKG2C+ NK cells. (A) g-NK cells persist and expand long-term in healthy individuals with prior HCMV infection, and their proportion will increase under the co-infection of HBV, HCV, HIV, and other chronic viruses. Exceptionally, a fraction of this subset has also been observed in HCMV- individuals. (B) g-NK cells characterized by FcRγ deficiency are different from NK cells marked by NKG2C and are composed of both NKG2C+ and NKG2C- subsets. In addition to this subset, adaptive NK cells comprise a subset of non-specifically recognized and HLA-E-specifically recognized NKG2C+ NK cells. These subgroups largely intersect. g-NK, γ chain-negative natural killer; HCMV, human cytomegalovirus; HBV, hepatitis B virus; HCV, hepatitis C virus; HIV, human immunodeficiency virus; FcϵRIγ or FcRγ, IgE receptor subunit-γ; EAT2, EWS/FLI1-activated transcript 2; SYK, spleen tyrosine kinase; and HLA-E, HLA class I histocompatibility antigen; alpha chain E.