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. 2022 Feb 2;53(5):1735–1745. doi: 10.1161/STROKEAHA.121.036997

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© 2022 The Authors.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — Progressive white matter change in hypoperfused mice. A, Tract-based spatial statistics on the mean fractional anisotropy (FA) map revealed shams (n=10) exhibited higher FA values than hypoperfused mice (n=6) in several white matter voxels at 3 and especially 6 m. Scale bar corresponds to t statistic, and entire white matter FA values were sham, 0.665±0.04; hypoperfused, 0.666±0.03 (3 mo); and sham, 0.737±0.03; hypoperfused, 0.714±0.05 (6 mo). B, Fiber direction and (C) probabilistic tractography images from representative animals. Color depicts direction: pink (left-right), green (superior-inferior), and blue (anterior-posterior).