Table 1. GPR151 associations with BMI.
| GRCh38 chr:pos | Reference allele | Alternate allele | HGVSp | Genotype counts (RR|RA|AA) | P-value | Beta [95% CI] kg/m2 (additive) | P-value (knockouts only) | Beta [95% CI] kg/m2 (knockouts only) |
|---|---|---|---|---|---|---|---|---|
| 5:146515831 | G | A | Arg95Ter | 27273|55|1 | 0.82 | -0.126 [-1.23–0.98] | ||
| 5:146515817 | G | T | Tyr99Ter | 26350|945|34 | 0.92 | 0.0131 [-0.24–0.27] | 0.55 | 0.431 [-0.99–1.85] |
| 5:146515587 | CTA | C | Phe175LeufsTer7 | 27206|120|3 | 0.28 | 0.406 [-0.32–1.14] | ||
| Gene Burden | 26150|1141|38 | 0.73 | 0.0405 [-0.20–0.28] | 0.98 | -0.021 [-1.37–1.33] |
chr, chromosome; pos, position; HGVSp, Human Genome Variation Society protein level change; R, reference allele; A, alternate allele; kg, kilograms; m, meter; CI, confidence interval