Table 2. Serological and virological status of animals exposed to HTLV-1WT and HTLV-1p12KO.
Treatment | HTLV-1WT | HTLV-1p12KO | ||||
---|---|---|---|---|---|---|
α-CD8/NK | α-CD8 | Clodrosome/Encapsome | α-CD8/NK | α-CD8 | Clodrosome | |
Seropositive | 3/3 | 3/3 | 1/5** | 4/4 | 1/4 | 1/5 |
Seroindeterminate | 0/3 | 0/3 | 4/5 | 0/4 | 3/4 | 4/5 |
Seronegative | 0/3 | 0/3 | 0/5 | 0/4 | 0/4 | 1/5 |
PCR gag | +2/3 | +3/3 | +3/3* | +4/4 | +3/4 | +4/4 |
PCR orf-I | +3/3 | +3/3 | +2/3* | +4/4 | +3/4 | +4/4 |
PCR gag/orf-I | +2/3 | +3/3 | +2/3* | +4/4 | +2/4 | +4/4 |
* Only three animals analyzed: P651, R257, H28J.
** Unsustained seroconversion
Animals ZJ22, Z151, and HPM treated with clodrosome, and ZJ58 treated with encapsosome, were not sacrificed and were enrolled in a subsequent study.