Table 2:
Outcomes, overall and in waves 1, 2 and 3
| Variable | No. (%) of patients* | |||
|---|---|---|---|---|
| Overall n = 1337 |
Wave 1 n = 520 |
Wave 2 n = 572 |
Wave 3 n = 245 |
|
| 28-day mortality† | 207 (15.5) | 95 (18.3) | 93 (16.3) | 19 (7.8) |
| In-hospital death | 238 (17.8) | 111 (21.3) | 103 (18.0) | 24 (9.8) |
| Admitted to intensive care unit | 495/1336 (37.1) | 201 (38.7) | 215 (37.6) | 79/244 (32.4) |
| Organ support during hospital stay | ||||
| All patients | ||||
| Invasive mechanical ventilation | 281 (21.0) | 130 (25.0) | 116 (20.3) | 35 (14.3) |
| Renal replacement therapy or dialysis | 68/1320 (5.2) | 33/511 (6.5) | 30/567 (5.3) | 5/242 (2.1) |
| Vasopressor | 285 (21.3) | 120 (23.1) | 123 (21.5) | 42 (17.1) |
| Patients admitted to intensive care unit | ||||
| Invasive mechanical ventilation | 276/495 (55.8) | 130/201 (64.7) | 111/215 (51.6) | 35/79 (44.3) |
| Renal replacement therapy or dialysis | 49/484 (10.1) | 25/193 (13.0) | 20/213 (9.4) | 4/78 (5.1) |
| Vasopressor | 276/495 (55.8) | 118/201 (58.7) | 117/215 (54.4) | 41/79 (51.9) |
| Organ support during first 14 d | ||||
| Invasive mechanical ventilation | 275 (20.6) | 127 (24.4) | 115 (20.1) | 33 (13.5) |
| Renal replacement therapy or dialysis | 55/1315 (4.2) | 26/508 (5.1) | 24/565 (4.2) | 5/242 (2.1) |
| Vasopressor | 278/1335 (20.8) | 116 (22.3) | 121/571 (21.2) | 41/244 (16.8) |
| DAF of invasive mechanical ventilation during first 14 d, mean ± SD | 10.8 ± 5.4 n = 1330 |
10.0 ± 5.9 n = 518 |
11.0 ± 5.3 n = 570 |
12.2 ± 4.3 n = 242 |
| DAF of renal replacement therapy during first 14 d, mean ± SD | 12.2 ± 4.6 n = 1319 |
11.8 ± 5.0 n = 509 |
12.3 ± 4.5 n = 567 |
13.1 ± 3.4 n = 243 |
| DAF of vasopressor first 14 d, mean ± SD | 11.3 ± 5.1 n = 1331 |
10.7 ± 5.5 n = 518 |
11.3 ± 5.0 n = 570 |
12.4 ± 3.9 n = 243 |
| Hospital length of stay, d | ||||
| Survivors | ||||
| Median (IQR) | 9.0 (5.0–19.0) | 13.0 (7.0–25.0) | 8.0 (5.0–15.0) | 9.0 (5.0–15.0) |
| Range | 2.0–135.0 | 2.0–135.0 | 2.0–77.0 | 2.0–66.0 |
| Decedents | ||||
| Median (IQR) | 11.0 (6.0–20.0) | 11.0 (6.0–21.0) | 11.0 (7.0–20.0) | 12.0 (9.5–24.0) |
| Range | 0.0–63.0 | 0.0–63.0 | 1.0–44.0 | 2.0–62.0 |
| Intensive care unit length of stay, d | ||||
| Survivors | ||||
| Median (IQR) | 8.0 (4.0–14.0) | 10.0 (4.0–17.0) | 7.0 (4.0–11.0) | 7.0 (2.0–13.5) |
| Range | 0.0–86.0 | 0.0–86.0 | 1.0–39.0 | 1.0–54.0 |
| Decedents | ||||
| Median (IQR) | 14.0 (6.0–24.0) | 15.0 (5.0–26.0) | 12.0 (7.0–21.0) | 16.0 (10.0–49.0) |
| Range | 0.0–61.0 | 0.0–61.0 | 0.0–38.0 | 3.0–57.0 |
Note: DAF = days alive and free, IQR = interquartile range, SD = standard deviation.
*
Except where noted otherwise.
†
Patients who were discharged alive before day 28 and were lost to follow-up were assumed to be survivors at day 28 (n = 185, 177 and 81 for waves 1, 2 and 3, respectively).