Figure 1. Phylogenetic tree of the SR protein family and their domain structure.

Human SR protein sequences were obtained from UniProt (last modified Feb 2, 2021) [19] and aligned with mafft, v7, L-INS-I method [20,21]. A maximum likelihood phylogenetic tree was produced with RAxML, v1.0.0, using LG + G4 as substitution model [22]. The domains were produced with DoMosaics utilizing the hmmer and Pfam protein domain database [23–25]. The annotations were manually curated according to [18].