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. 2022 Feb 15;50(1):13–20. doi: 10.1042/BST20211114

Figure 1. Scheme of TNF signalling including proteins involved in TNF-induced apoptosis and necroptosis.

Figure 1.

Signalling is primarily mediated through PTMs like phosphorylation and ubiquitylation. Hence, most proteins involved in this signalling are found to be phosphorylated.