Table 1. Clinical spectrum of disease in LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre (KPC) mice.
| Sr. no. | Age (days) | Sex/animal ID | Histological diagnosis | Metastasis | Ascites | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liver | Lung | Diaphragm | Spleen | Stomach | Intestine | Kidneys | Adrenals | |||||
| 1 | 60 | F2 | Lymphoma | N | N | N | N | N | N | N | N | N |
| 2 | 126 | F3 | Invasive ductal carcinoma (moderately differentiated) | Y | Y | Y | N | N | N | N | N | Y |
| 3 | 153 | F4 | Invasive ductal carcinoma (moderately differentiated) | Y | N | Y | N | N | Y | N | N | Y |
| 4 | 219 | F6 | Invasive ductal carcinoma (moderately to poorly differentiated) | Y | Y | N | N | N | N | N | N | Y |
| 5 | 118 | F7 | Invasive ductal carcinoma (moderately to poorly differentiated) | N | N | N | N | Y | N | N | N | N |
| 6 | 90 | F10 | Sarcomatoid carcinoma of pancreas | N | N | N | N | N | N | N | N | Y |
| 7 | 90 | M4 | Malignant lymphoma | N | N | N | N | N | N | N | N | Y |
| 8 | 114 | M9 | Invasive ductal carcinoma (poorly differentiated) | Y | Y | Y | Y | Y | Y | N | N | Y |
| 9 | 118 | F6 | Tissues not evaluated due to necrosis. Had tumor in pancreas | * | * | * | * | * | * | * | * | N |
| 10 | 194 | M4 | Invasive ductal carcinoma | N | Y | Y | N | Y | N | N | N | Y |
| 11 | 130 | M3 | Pancreas cystic lesion | N | N | N | N | N | N | N | N | N |
| Total | 7/11 | 4/10 | 4/10 | 4/10 | 1/10 | 3/10 | 2/10 | 0/10 | 0/10 | 7/10 | ||
Y, yes; N, no; *, tissue not evaluated.