Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 7;9:853409. doi: 10.3389/fnut.2022.853409

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Dai, Liu, Abasubong, Zhang, Li, Xiao, Wang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

A schematic diagram shows key molecular pathways involved in the penetration of LPS induced by high-fat diet. Consumption of high-fat diets increases the penetration of LPS, which induces low-grade chronic inflammation; Consumption of high-fat diets inhibit the secretion of MUC2 by activating the IRE1/XPB-1 signaling pathway in goblet cells; Fatty acids assist in the cellular internalization of LPS and then activate its intracellular signaling pathway depending on CD36 in intestinal epithelial cells.