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. 2022 Apr 22;298(6):101972. doi: 10.1016/j.jbc.2022.101972

Figure 2.

Figure 2

Structural characterization of nirmatrelvir bound to SARS-Cov-2 MproVOC.AC, superposition of the x-ray crystal structures of nirmatrelvir bound to wildtype SARS-CoV-2 Mpro (gray) and (A) SARS-Cov-2 Mpro P132H (in magenta and green), (B) G15S (in cyan and green), and (C) K90R (in orange and green). D, ribbon figure of the three VOC crystal structures superposed on the WT, highlighting the location and distance of the mutant residues (in stick representation) in relation for the nirmatrelvir-binding site. Colors are maintained from AC. VOC, variant of concern.