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. 2022 Apr 22;298(6):101972. doi: 10.1016/j.jbc.2022.101972

Table 1.

Enzymatic catalytic constants for SARS-CoV-2 Mpro enzyme

SARS-CoV-2 Predominant enzyme mutation Km (μM) Kcat S−1 kcat/Km S−1 M−1 n
USA-WA1 Wildtype 26.4 ± 9.8 0.76 ± 0.41 31,500 ± 18,600 14
Lambda, λ
B.1.1.1.37		 G15S 67.7 ± 18.6 1.18 ± 0.6 16,500 ± 5400 4
Alpha, α
B1.1.7
Beta, β
B.1.351
Gamma, γ
P.1		 K90R 35.8 ± 17.3 0.9 ± 0.48 28,300 ± 12,600 8
Omicron, ο
B.1.1.529		 P132H 25.2 ± 11.7 0.45 ± 0.14 20,800 ± 9350 4