Table 4.
SARS-CoV-2 deuterium exchange summary (wildtype, P132H, G15S, K90R Mpro)
| Dataset | CoV-2_WT (control) | Cov-2_P132H | Cov-2_G15S | Cov-2_K90R |
|---|---|---|---|---|
| HDX reaction details | 4C | 4C | 4C | 4C |
| HDX time course (s) | 15, 60, 360, 3600 | 15, 60, 360, 3600 | 15, 60, 360, 3600 | 15, 60, 360, 3600 |
| # of peptides | 405 | 387 | 326 | 339 |
| Sequence coverage | 100.00% | 100.00% | 99.02% | 99.02% |
| Average peptide length/Redundancy | 17.24/22.82 | 17.29/21.86 | 16.33/17.39 | 16.65/18.44 |
| Replicates | 4 | 4 | 4 | 4 |
| Repeatability (avg. stddev of #D) | 0.1123 | 0.1200 | 0.1777 | 0.1412 |
| Significant differences in HDX (delta HDX > X D - 95% CI) | n/a | 0.3123 D | 0.373 D | 0.3657 D |