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. 2022 Apr 5;50(7):4100–4112. doi: 10.1093/nar/gkac222

Figure 4.

Figure 4.

Polymorphisms disrupting GoU base pairs reach lower frequencies than other SNPs at identical positions. At each GoU position listed in Figure 3, we compare the average allele frequency for SNPs disrupting GoU base pairs to the average allele frequency of SNPs at the same Sprinzl positions across all other tRNAs. We find that for 20 of 24 comparisons, SNPs disrupting GoU base pairs reach a lower frequency (sign test, P < 6.3 × 10–4) and are above the diagonal line shown here. We used data from dbSNP for these comparisons (see Methods) (55).