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. 2022 Mar 23;50(7):4127–4147. doi: 10.1093/nar/gkac182

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — (A) CD spectra of parallel promoter G4s with three G-quartet stacks from the literature. (B) CD spectra of d[TG_nT]₄ oligos normalized to G4 concentration. (C) Linear relationship of the 264 nm CD signal normalized by G4 concentration of parallel d[TG_nT]₄ G4s (black squares) versus number of contiguous stacked G-quartets. The line of best fit is shown in red. The blue triangles show the 264 nm magnitudes for the promoter sequences in (A), the magnitude of the 9-quartet hTERT (52), and the TG₂T sequence (which does not form a G4). The light gray vertical lines cross the regression at the 264 nm values obtained for the extended promoter 8-tract and 12-tract sequences (shown in D). (D) CD spectra of the 8-tract and 12-tract promoter sequences studied here.