Figure 1.

Copy-number alteration drivers are present in tumors with insufficient SNV drivers. (A) Model for oncogene accumulation by CNAs to drive cancer initiation and progression. (B) TCGA tumors were analyzed for the number of tumors with insufficient SNV drivers. Tumors were queried for 251 Tier 1 COSMIC oncogenes and tumor suppressor gene mutations. Tumors with only p53, or with p53 and mutations commonly found in normal human epithelium (includes NOTCH1-3, FGFR3 and FAT1) and no other COSMIC OG or TSG mutation are plotted as a percent of all tumors queried. (C) Frequency of CNAs in the same cancer types. Stacked bars represent cumulative CNAs of any type. (D) COSMIC Tier1 cancer genes overlapping deletion CNAs (for TSGs) or amplification CNAs (for OGs).