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Population PK modeling for evernimicin: mean parameter vector and covariance matrixa
| Value | Volume of central compartment (liters) | Plasma clearance (liters/h) | Kcp (h−1) | Kpc (h−1) |
|---|---|---|---|---|
| Mean | 6.36 | 2.46 | 0.302 | 0.089 |
| Covariance matrix | 3.8096 | |||
| 0.0530 | 0.0034 | |||
| 0.0063 | 0.0001 | 0.0003 | ||
| 1.0481 | 0.0120 | 0.0051 | 0.5551 |
Population pharmacokinetic analysis was for 52 subjects, including 4 each with Child-Pugh Class A, B, and C cirrhosis. Overall, 1,689 plasma samples were analyzed.
