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. 2021 Dec 1;480(4):725–737. doi: 10.1007/s00428-021-03244-w

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© The Author(s) 2021

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Fig. 1 — A: Example of a STIC, with H&E showing aberrant morphology (A-1), p53 overexpression (A-2), and a high Ki-67 labelling index (A-3). B: Example of a STIL, with H&E showing moderately aberrant morphology (B-1), p53 overexpression (B-2), and a low Ki-67 labelling index (B-3). C: Example of a P53 signature, with no aberrant morphology (C-1) p53 overexpression (C-2) and a low Ki-67 labelling index (C-3)