Fig. 3. Reduction in recurrence with RT was independent of primary tumour HIF-α status.

Cumulative incidence of IBTR after surgery of the primary tumour (a–c), any recurrences (d–f) as first event, and BCD (g–i) in 985 T1-2N0M0 breast cancer patients randomised to RT (green line) or no RT (orange line) after breast-conserving surgery for all primary tumours (a, d, g), HIF-1α positive primary tumours (b, e, h), and HIF-1α negative primary tumours (c, f, i).