Table 5.

Diagnostic accuracy of SEC13, GHRL, lncRNA GHRLOS, SMAD7, HIF-1α genes expression, serum HIF-1α and CEA levels.

	AUC	Cut off#	Sensitivity	Specificity	95% CI	PPV	NPV	Accuracy	P
SEC13	0.816	≤ 0.389	80.0	72.0	0.734 –0.898	74.1	78.3	76.0	< 0.001*
GHRL	0.630	≤ 0.390	60.0	58.0	0.521 –0.739	58.8	59.2	59.0	0.026*
LncRNA GHRLOS	0.968	≤ 0.030	90.0	98.0	0.930 –1.000	97.8	90.7	94.0	< 0.001*
SMAD7	0.631	> 0.752	70.0	62.0	0.518 –0.743	64.8	67.4	66.0	0.024*
HIF-1α	0.724	> 0.895	84.0	68.0	0.617 –0.831	72.4	81.0	76.0	< 0.001*
HIF-1α protein	1.000	> 2.180	100.0	100.0	1.000 –1.000	100.0	100.0	100.0	< 0.001*
CEA protein	0.961	> 3.980	92.0	90.0	0.926 –0.996	90.2	91.8	91.0	< 0.001*

CI: Confidence intervals, AUC: area under the curve, PPV: positive predictive value, NPV: negative predictive value.

*Statistically significant at P ≤ 0.05.

^#Cut off was choose according to Youden index.