Fig. 10. Therapeutic effect of different AIEgens in vivo.

(a) Fluorescent image of mice after intratumoral injection of TPE-PyT-CPS (0.1 mM, 120 μL) for 18 h. (b) Photographs of excised tumors on the 15th day in different groups (1. saline + L, 2.TPE-PyT-PS, 3.TPE-T-CPS, 4.TPE-PyT-CPS, 5.TPE-PyT-PS + L, 6.TPE-T-CPS + L, 7.TPE-PyT-CPS + L). (c) Changes of tumor volume and weight (d) during PDT that treated with different AIEgens (0.2 mM, 100 μL in saline) as the PS under 532 nm laser irradiation of 35 mW cm⁻² for 5 min (n = 5 animals). (e) Body weight curves of mice during PDT treatment in different treating groups (n = 5 animals). (f) H&E staining (scale bar: 50 μm) and apoptotic analysis of TUNEL staining (scale bar: 20 μm) images of tumor slices from mice after treatment with saline and TPE-PyT-CPS under 532 laser irradiations. The experiments in 10a and 10 f were performed from biologically independent animals (n = 3), representative images are shown. Data in 10c, d, e are presented as mean ± SD (n = 5 animals). Statistically significant differences between the experimental groups were analyzed by two-tailed Student’s t-test. when p < 0.05, it was considered to have statistical significance. Source data are provided as a Source Data file.