TABLE 2.

Summary of pharmacodynamic categorical analysis of associations between concentrations and adverse events (n = 42)

Adverse event	n	Associationa with:
		Cmax,ss	Cavg,ss	Cmin,ss
Nausea and/or vomiting	12	0.21	0.05	0.15
Headache	11	0.01	0.07	0.34
Diarrhea	12	0.44	0.92	0.92
Rash	4	0.96	0.28	0.96
Oral numbness	5	0.02	0.02	0.18

^aValues are P values from the Mantel-Haenszel chi-square test with modified Ridits scores. Parameter values were categorized as greater or less than the median.