TABLE 3.
Predicted ECs of amprenavir for various decreases in plasma HIV RNA AAUCMB calculated for Cmax,ss, Cmin,ss, and Cavg,ss using the sigmoid Emax model
| EC level | Cmin,ss (μg/ml) | AAUCMB (−log10 copies/ml) | Cavg,ss (μg/ml) | AAUCMB (−log10 copies/ml) | Cmax,ss (μg/ml) | AAUCMB (−log10 copies/ml) |
|---|---|---|---|---|---|---|
| EC50 | 0.087 | 0.60 | 0.506 | 0.60 | 2.233 | 0.61 |
| EC75 | 0.141 | 0.89 | 0.793 | 0.90 | 3.702 | 0.91 |
| EC90 | 0.228 | 1.07 | 1.243 | 1.09 | 6.139 | 1.09 |
| EC95 | 0.318 | 1.13 | 1.687 | 1.15 | 8.661 | 1.15 |
| EC99 | 0.658 | 1.18 | 3.310 | 1.19 | 18.510 | 1.20 |
| Emax | 1.19 | 1.21 | 1.21 |