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. 2022 Apr 21;12:6569. doi: 10.1038/s41598-022-10330-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Frequency of activated platelets in HICs and control groups. (A) Frequencies of CD62P⁺ platelets; (B) Median fluorescence intensity of CD62P in the platelet population; (C) Spearman correlations between activation of platelets and other markers evaluated in the study; Colored horizontal bars represent the IQR and sample median, while gray boxplots represent linear model estimated marginal sample-bias adjusted means and its 95% confidence intervals (CI 95%). Comparisons of estimated marginal means among groups were performed by T-tests of contrasts obtained after multivariate-linear models fitted by ordinary least square regressions. p-values were corrected by the Tukey Honest Significant Difference post hoc method and represented as: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Comparison graphs were plotted with Graphpad Prism v9 and correlation graphs were plotted with R software v4.1.