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. 2022 Apr 21;12:6548. doi: 10.1038/s41598-022-10311-y

Figure 3.

Figure 3

The impact of K3, K4, and K7 (1 µM) on sensitive HOC spheroid area after 24, 48, and 72 h exposure (A). Representative images of sensitive HOC spheroids at 0–72 h of experiment (B), scale bar = 500 µm. The control spheroids (C) were treated with 1% V/V DMSO. After incubation, the spheroid areas were determined and the spheroid growth was calculated (A, relative to control). Data are expressed as the average of spheroid growth (%) of nine repetitions with the corresponding standard error of the mean. The statistical differences between the control spheroids and treated spheroids were calculated by using a two-compound t-test at the level *p < 0.05, **p < 0.01, ***p < 0.001.