. 2022 Apr 21;12:6548. doi: 10.1038/s41598-022-10311-y

Table 7.

Cytotoxic activity of selenoesters against 3D ovarian (HOC) and breast (MCF-7) cancer cell models and their Adriamycin (HOC/ADR) and paclitaxel (MCF-7/PAX) resistant sub-models.

Cpd	HOC	IC₅₀ [µM]		MCF-7/PAX
Cpd	HOC	HOC/ADR	MCF-7	MCF-7/PAX
K3	1.7 ± 0.1^a	3.9 ± 0.2^a	2.5 ± 0.2^a	4.0 ± 0.1^a
K4	3.1 ± 0.1^b	10.5 ± 0.5^b	2.1 ± 0.0^a	4.8 ± 0.3^a
K7	2.8 ± 0.1^b	10.1 ± 0.5^b	2.2 ± 0.3^a	7.5 ± 0.2^b

Data are expressed as the average inhibitory concentration (IC₅₀) of four repetitions with standard error of the mean (SEM). The statistical differences between compounds were calculated by one-way analysis of variance (ANOVA) and Duncan’s post hoc test (p ˂ 0.05) within one cell line, where different letters (a, b) denoted the significances; the different cell lines were evaluated independently on each other.