Skip to main content
. 2021 Nov 8;126(8):1113–1124. doi: 10.1038/s41416-021-01600-w

Fig. 1. A product of AS of pre-mRNA: lncRNA.

Fig. 1

a Splicing factor hnRNPE1 promotes proximal 5′ splice‐site selection in exon 12, thus inducing the production of PNUTS mRNA. The absence of hnRNPE1 facilitates the generation of the lncRNA-PNUTS isoform, which promotes tumour development by competitively binding with miR-205 to upregulate ZEB1. b IFNγ promotes the generation of the PD-L1-lnc isoform and PD-L1-lnc activates the transcriptional activity of c-myc through the formation of a heterodimer with Max to promote the development of tumours. c In oral squamous cell carcinoma, exon 2 and 3 skipping of ORAOV1 pre-mRNA leads to the formation of the lncRNA ORAOV1-B isoform, which activates the TNF-κB/TNFα loop pathway by binding with HSP90.