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. 2022 Apr 8;9:851603. doi: 10.3389/fcvm.2022.851603

FIGURE 1.

FIGURE 1

Irisin inhibits nicotine-mediated atherosclerosis in Apoe–/– mice. (A) En-face Oil red O staining of aortas from the Control group, Nicotine group, Irisin group, Nicotine + Irisin group and Nicotine + Irisin + Cilengitide group, n = 2. (B) Cross sections of aortic root stained with Oil red O dye and immunofluorescence of CD31. (C) Quantification of aortic root with Oil red O staining, n = 6. (D) Quantification of abdominal aorta stained with CD31, n = 6. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. Data are mean ± SD; ns, no significance.