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. 2022 Apr 8;9:851603. doi: 10.3389/fcvm.2022.851603

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Copyright © 2022 Chen, Li, Shao, Lai, Gao, Wang, Song, Guo, Yu, Du, Zhu, Wang, Ma, Xu, Zhou, Liu, Shu, Zhao, Wang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentially expressed genes (DEGs) and enrichment analyses of endothelial cells treated with nicotine and irisin. (A) Correlation analysis of DEGs in the Control group (C), Nicotine group (Ni) and Nicotine + Irisin group (Ni_Ir). (B) Heatmap of the top 1,000 DEGs among the three groups. (C) Volcano plot of DEGs between the Ni group and C group (padj < 0.05, | log2fold change| > 1); (D) Volcano plot of DEGs between the Ni_Ir group and Ni group (padj < 0.05, | log2fold change| > 1); (E) KEGG pathway enrichment analysis of DEGs between the Ni group and C group; (F) KEGG pathway enrichment analysis of DEGs between the Ni_Ir group and Ni group.