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. 2022 Apr 8;9:851603. doi: 10.3389/fcvm.2022.851603

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Copyright © 2022 Chen, Li, Shao, Lai, Gao, Wang, Song, Guo, Yu, Du, Zhu, Wang, Ma, Xu, Zhou, Liu, Shu, Zhao, Wang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic model of the mechanism by which irisin suppresses nicotine-mediated migration, proliferation, cell cycle arrest, and cell senescence in endothelial cells. [Irisin’s protein data bank (PDB) ID: 4LSD (42, 43)].