TABLE 1.

Differential metabolites between APA and EHT patients.

Positive ion mode				Negative ion mode
Name	VIP	Fold change (APA vs EHT)	p value	Name	VIP	Fold change (APA vs EHT)	p value
Glycerophosphocholine	4.39	0.22	0.00	(+-)12-HETE	7.36	0.11	0.00
L-Histidine	2.13	0.29	0.00	L-Glutamate	5.55	0.41	0.00
N6-Methyl-L-lysine	1.34	0.37	0.05	Succinate	1.36	0.52	0.00
Trigonelline	1.18	0.45	0.01	L-Aspartate	1.77	0.59	0.00
D-Proline	3.60	0.48	0.00	1-Oleoyl-L-.alpha.-lysophosphatidic acid	1.31	0.59	0.01
L-Glutamate	1.53	0.50	0.00	Hydroxyisocaproic acid	2.36	0.64	0.02
Betaine	2.73	0.51	0.00	D-Quinovose	1.88	0.66	0.05
Ornithine	1.21	0.53	0.01	2-Hydroxy-3-methylbutyric acid	2.96	0.66	0.05
2-Methylbutyroylcarnitine	1.64	0.55	0.02	Ammelide	1.17	0.81	0.00
L-Lysine	1.36	0.55	0.03	Hypoxanthine	7.53	1.49	0.02
L-Glutamine	3.60	0.62	0.00	3-Hydroxycapric acid	2.70	1.52	0.02
1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine	1.80	0.62	0.01	Bisindolylmaleimide I	2.82	2.35	0.03
(3-Carboxypropyl) trimethylammonium cation	2.59	0.62	0.00	pregnenolone sulfate	4.36	2.38	0.04
L-Citrulline	1.06	0.66	0.02	5(S)-HpETE	2.95	32.38	0.00
L-Leucine	2.07	0.68	0.02	Phenol	6.98	0.51	0.06
1-Oleoyl-sn-glycero-3-phosphocholine	5.60	0.68	0.05	D-Sorbitol	1.14	0.57	0.08
Nicotinamide	1.56	0.73	0.04	L-Iditol	2.14	0.65	0.05
L-Carnitine	10.97	0.77	0.00	Capric acid	1.28	0.75	0.07
Taurine	1.75	0.83	0.02	L-Proline	2.01	0.81	0.09
Sphingomyelin (d18:1/18:0)	2.22	1.34	0.02	L-Glutamine	1.10	0.87	0.09
Hypoxanthine	2.26	1.55	0.02	2-Oxoadipic acid	8.58	1.03	0.08
Thioetheramide-PC	1.03	1.56	0.04	Cholesterol 3-sulfate	8.38	1.39	0.07
L-Arginine	4.99	0.57	0.05

All significantly differential metabolites (VIP >1, p < 0.05) are shown in bold and differential metabolites (VIP >1, 0.05 ≤ p < 0.1) are shown in regular font.

Bold values represents the significant differential metabolites.