TABLE 2.

Differential metabolites between preoperative and postoperative APA patients.

Positive ion mode				Negative ion mode
Name	VIP	Fold change (postoperative vs. preoperative)	p value	Name	VIP	Fold change (postoperative vs. preoperative)	p value
Trimethylamine N-oxide	1.70	0.32	0.04	Pyrocatechol	1.95	0.08	0.00
Trigonelline	2.21	0.33	0.00	3-Indolepropionic acid	2.68	0.18	0.02
Nicotinamide	3.71	0.38	0.00	Indoxyl sulfate	10.53	0.48	0.03
L-Lysine	2.18	0.48	0.01	Hypoxanthine	9.58	0.55	0.00
Allopurinol riboside	2.86	0.50	0.01	Cholesterol 3-sulfate	13.22	0.60	0.00
Inosine	5.45	0.53	0.01	1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine	1.34	0.76	0.01
Uracil	1.09	0.60	0.00	Taurine	1.90	1.25	0.05
Hypoxanthine	15.68	0.63	0.02	D-Mannose	1.24	1.50	0.01
Phthalic acid Mono-2-ethylhexyl Ester	1.70	0.64	0.03	D-Lyxose	1.62	1.57	0.01
Glycerophosphocholine	3.58	0.65	0.03	Methylmalonic acid	1.45	1.77	0.00
L-Citrulline	1.36	0.66	0.01	D-Threitol	1.02	1.98	0.00
1-Palmitoyllysophosphatidylcholine	1.23	0.67	0.01	myo-Inositol	1.33	2.15	0.02
1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine	1.66	0.74	0.01	Acetoacetic acid	1.33	2.21	0.00
1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine (SOPC)	13.56	1.24	0.05	D-Maltose	1.28	8.55	0.00
L-Carnitine	16.64	1.40	0.03	Chenodeoxycholate	1.49	0.31	0.07
Phe-Ile	1.26	2.04	0.01	Allantoin	1.97	0.84	0.07
Cellobiose	1.99	7.37	0.00	DL-3-Phenyllactic acid	1.32	1.66	0.06
N1-Methyl-2-pyridone-5-carboxamide	3.32	0.50	0.06
Decanoyl-L-carnitine	2.99	0.64	0.09
1-Oleoyl-sn-glycero-3-phosphocholine	8.81	0.72	0.05
1-Palmitoyl-sn-glycero-3-phosphocholine	2.38	0.81	0.08
Betaine	1.75	0.83	0.08
(3-Carboxypropyl) trimethylammonium cation	3.34	1.61	0.06

All significantly differential metabolites (VIP >1, p <0.05) are shown in bold and differential metabolites (VIP >1, 0.05 ≤ p <0.1) are shown in regular font.

Bold values represents the significant differential metabolites.