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. 2022 Apr 8;10:828128. doi: 10.3389/fcell.2022.828128

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Copyright © 2022 Yang, Xuan, Chen, Cao, Zhao, Wang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiRNAs regulate Wnt/β-catenin signaling pathway and EMT in CRC. In the absence of Wnt, β-catenin forms a complex with APC, GSK3 and Axin. The β-catenin is phosphorylated by GSK3β and targeted for ubiquitin-dependent proteasomal degradation. This figure summarizes the interaction between miRNAs and the Wnt/β-catenin signaling pathway in CRC and a subset of downstream miRNAs that are involved in the EMT process. During the process of EMT, the expression of mesenchymal markers, including N-cadherin and vimentin, is up-regulated, and the expression of the epithelial markers, including E-cadherin and ZO-1, is down-regulated. miR, microRNA; EMT, epithelial-to-mesenchymal transition; APC, Adenomatous Polyposis Coli; TCF, T-cell factor.