TABLE 1.

List of most promising miRNA biomarkers in Colorectal Cancer.

Biomarker type	Sample type	miRNA	References
Diagnosis	Blood	miR-21, miR-92a, miR-20a, miR-29a, miR-223	(Huang et al., 2010; Du et al., 2014; Zheng et al., 2014; Yamada et al., 2015; Chang et al., 2016; Moody et al., 2019)
	Stool	miR-21, miR-17–92 cluster, miR-20a, miR-135b, miR-223, miR-421/miR-27a	(Koga et al., 2010; Wu et al., 2012; Rashid et al., 2020; Duran-Sanchon et al., 2021)
Prognosis	Blood	miR-21, miR-31, miR-34a, miR-155, miR-200 family	(Toiyama et al., 2013; Chen et al., 2014; Schou et al., 2014; Maierthaler et al., 2017; Yuan et al., 2017)
	Tissue	miR-21, miR-31, miR34a, miR-224, miR-92a	(Siemens et al., 2013; Zhang et al., 2013; Gao et al., 2015; Slattery et al., 2015; Ling et al., 2016; Mima et al., 2016)
Prediction of response to treatment	Blood/Tissue	miR-21, miR-31, miR-143/-145, miR-106	(Schetter et al., 2008; Drebber et al., 2011; Kjersem et al., 2014; Lopes-Ramos et al., 2014; Igarashi et al., 2015; Caramés et al., 2016)