TABLE 3.

NIPA1 mutation rate in different regions.

Region	Result	References
China	3.6% (2/55) HSP	Lu et al. (2018)
	8.6% (3/35) HSP	this study
Japan	0/129 HSP	Ishiura et al. (2014)
Korea	0/104 HSP	Yang et al. (2021)
Italy	0/239 HSP	D'Amore et al. (2018)
Gemany	0/101 HSP	Beetz et al. (2008)
Europe (France)	0.9% (1/110) ADHSP	Klebe et al. (2007)
Hungary	1.7% (1/58) HSP	Balicza et al. (2016)
Denmark	1.9% (1/52) HSP (30 ADHSP and 22 sporadic cases)	Svenstrup et al. (2011)

ADHSP, autosomal dominant hereditary spastic paraplegia.