Table 2.
The Role of lncRNAs in SSc.
| lncRNA | Function | Tissue and cell | Expressed in SSc | reference | |
|---|---|---|---|---|---|
| Microvascular changes | SMILR | Promoted cells proliferation by interacting with CENPF mRNA and STAU1. | VSMCs | up | (56) |
| OTUD6B-AS1 | Inhibited cells proliferation and suppressed apoptosis, led to cell dysregulation on the fibrosis and microangiopathy by increasing Cyclin D1 expression, | fibroblasts,HPASMCs | down | (57) | |
| Immune activation | NRIR | Destroyed autoinflammation homeostasis by inducing IFN response, associated with severe clinical phenotypes. | monocytes | up | (11) |
| PSMB8-AS1 | Promoted cells activation and proinflammatory cytokines secretion. | monocytes | up | (58) | |
| Fibrosis | H19X | Promoted ECM production, myofibroblast activation and inhibiting cells apoptosis by binding to DDIT4L. | fibroblasts, skin, lung | up | (59) |
| HOTAIR | Promoted cell profibrotic activation by inducing H3K27me3 in miR-34a. | skin, fibroblasts | up | (60, 61) | |
| TSIX | Promoted fibrosis by enhancing collagen mRNA stability and expression. | fibroblasts | up | (62) |