TABLE 1.
MICs of 210 H. influenzae and 50 M. catarrhalis strains
| Drug | β-lactamase-positive H. influenzae (82)a
|
β-lactamase-negative H. influenzae (128)
|
All H. influenzae (210)
|
M. catarrhalis (50)
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | |
| ABT-773 | 1.0–8.0 | 4.0 | 4.0 | 1.0–8.0 | 4.0 | 4.0 | 1.0–8.0 | 4.0 | 4.0 | 0.125–0.5 | 0.125 | 0.25 |
| Erythromycin | 2.0–16.0 | 8.0 | 16.0 | 2.0–>16.0 | 8.0 | 16.0 | 2.0–>16.0 | 8.0 | 16.0 | 0.25–1.0 | 0.5 | 0.5 |
| Azithromycin | 1.0–4.0 | 2.0 | 4.0 | 0.5–4.0 | 2.0 | 4.0 | 0.5–4.0 | 2.0 | 4.0 | 0.06–0.25 | 0.125 | 0.125 |
| Clarithromycin | 4.0–16.0 | 16.0 | 16.0 | 4.0–>32.0 | 8.0 | 16.0 | 4.0–>32.0 | 8.0 | 16.0 | 0.25–0.5 | ≤0.25 | ≤0.25 |
| Roxithromycin | 4.0–32.0 | 16.0 | 32.0 | 8.0–>32.0 | 16.0 | 32.0 | 4.0–>32.0 | 16.0 | 32.0 | 0.5–2.0 | 1.0 | 1.0 |
| Amoxicillin | 4.0–>16.0 | >16.0 | >16.0 | 0.125–2.0 | 0.5 | 1.0 | 0.125–>16.0 | 1.0 | >16.0 | 2.0–>16.0 | 8.0 | >16.0 |
| Amoxicillin-clavulanate | 0.5–4.0 | 1.0 | 2.0 | 0.125–2.0 | 0.5 | 1.0 | 0.125–4.0 | 1.0 | 2.0 | 0.125–0.5 | ≤0.125 | 0.25 |
| Cefuroxime | 0.25–8.0 | 0.5 | 1.0 | 0.25–4.0 | 0.5 | 1.0 | 0.25–8.0 | 0.5 | 1.0 | 0.25–8.0 | 2.0 | 4.0 |
| Cefixime | 0.008–0.06 | 0.03 | 0.06 | 0.008–0.125 | 0.03 | 0.03 | 0.008–0.125 | 0.03 | 0.06 | 0.008–1.0 | 0.25 | 0.5 |
| Cefpodoxime | ≤0.125–0.25 | ≤0.125 | ≤0.125 | ≤0.125–0.25 | ≤0.125 | ≤0.125 | ≤0.125–0.25 | ≤0.125 | ≤0.125 | 0.25–4.0 | 1.0 | 2.0 |
| Cefprozil | 1.0–>32.0 | 4.0 | 16.0 | 0.5–16.0 | 2.0 | 4.0 | 0.5–>32.0 | 4.0 | 8.0 | 0.25–>32.0 | 4.0 | 8.0 |
| Ceftriaxone | ≤0.004–0.016 | ≤0.004 | 0.008 | ≤0.004–0.016 | ≤0.004 | ≤0.004 | ≤0.004–0.016 | ≤0.004 | ≤0.004 | 0.016–2.0 | 0.5 | 2.0 |
a
Number of strains.