TABLE 2.

Results of kill kinetics studies for 10 H. influenzae strains

Drug and concn	No. of strains
	3 h			6 h			12 h			24 h
	−1a	−2	−3	−1	−2	−3	−1	−2	−3	−1	−2	−3
ABT-773
4 × MIC	7	5	2	8	5	5	10	8	5	10	10	10
2 × MIC	6	2	1	8	5	4	10	7	5	10	10	9
MIC	2	1	0	4	2	0	8	4	4	10	10	6
0.5 × MIC	0	0	0	0	0	0	0	0	0	0	0	0
Erythromycin
4 × MIC	5	2	1	7	5	2	10	6	5	10	10	9
2 × MIC	5	1	1	6	4	1	10	6	4	10	10	8
MIC	2	0	0	4	0	0	8	2	1	9	8	5
0.5 × MIC	0	0	0	0	0	0	1	0	0	0	0	0
Azithromycin
4 × MIC	7	4	3	10	6	5	10	10	9	10	10	10
2 × MIC	4	3	1	9	5	3	10	10	7	10	10	10
MIC	3	1	0	6	2	0	9	4	3	9	9	7
0.5 × MIC	0	0	0	0	0	0	1	1	0	1	1	0
Clarithromycin
4 × MIC	5	2	0	8	5	2	10	6	5	10	10	9
2 × MIC	4	1	0	7	4	2	10	5	4	10	10	9
MIC	1	0	0	2	0	0	8	2	0	7	7	3
0.5 × MIC	0	0	0	0	0	0	0	0	0	0	0	0
Roxithromycin
4 × MIC	5	3	1	8	5	2	10	6	5	10	10	9
2 × MIC	4	2	1	7	4	2	9	6	4	10	10	9
MIC	2	0	0	3	1	0	6	4	3	7	7	3
0.5 × MIC	0	0	0	0	0	0	0	0	0	0	0	0
Amoxicillin
4 × MIC	6b	0	0	8	2	0	8	7	3	8	8	8
2 × MIC	4	0	0	7	0	0	8	5	1	8	8	7
MIC	3	0	0	5	0	0	5	3	0	6	4	3
0.5 × MIC	0	0	0	0	0	0	1	0	0	1	0	0
Amoxicillin-clavulanate
4 × MIC	4	1	0	9	3	0	10	9	3	10	10	9
2 × MIC	3	0	0	9	3	0	10	9	3	10	10	9
MIC	3	0	0	7	2	0	10	4	2	10	7	5
0.5 × MIC	0	0	0	0	0	0	1	0	0	1	0	0
Cefuroxime
4 × MIC	5	0	0	10	2	0	10	9	4	10	10	10
2 × MIC	4	0	0	9	2	0	10	8	3	10	10	8
MIC	2	0	0	5	0	0	8	4	1	8	8	6
0.5 × MIC	0	0	0	1	0	0	2	0	0	1	0	0
Cefixime
4 × MIC	4	1	0	8	5	1	9	7	5	10	10	10
2 × MIC	4	0	0	8	5	1	10	8	3	10	10	9
MIC	3	0	0	8	4	0	10	8	3	10	10	8
0.5 × MIC	0	0	0	1	0	0	2	1	0	2	0	0
Cefpodoxime
4 × MIC	5	1	0	8	4	0	10	7	2	10	10	9
2 × MIC	3	0	0	8	5	0	10	8	4	10	10	9
MIC	3	0	0	7	4	0	9	6	3	10	9	7
0.5 × MIC	1	0	0	1	0	0	3	0	0	0	0	0
Cefprozil
4 × MIC	5	0	0	10	6	0	10	10	6	10	10	10
2 × MIC	4	0	0	10	4	0	10	8	5	10	10	10
MIC	1	0	0	5	2	0	9	3	2	9	8	6
0.5 × MIC	0	0	0	2	0	0	1	0	0	0	0	0
Ceftriaxone
4 × MIC	3	0	0	8	6	2	10	8	6	10	10	9
2 × MIC	3	0	0	8	5	1	10	8	6	10	10	9
MIC	2	0	0	8	3	0	10	8	3	10	9	8
0.5 × MIC	0	0	0	0	0	0	3	0	0	0	0	0

^aΔLog₁₀ CFU per milliliter lower than at 0 h. 

^bOnly tested against β-lactamase-negative strains.