TABLE 3.
Results of kill kinetics studies for five M. catarrhalis strainsa
| Drug and concn | No. of strains
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 h
|
6 h
|
12 h
|
24 h
|
|||||||||
| −1b | −2 | −3 | −1 | −2 | −3 | −1 | −2 | −3 | −1 | −2 | −3 | |
| ABT-773 | ||||||||||||
| 4 × MIC | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 3 | 0 | 5 | 5 | 5 |
| 2 × MIC | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 5 | 5 | 4 |
| MIC | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 5 | 3 |
| 0.5 × MIC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
| Erythromycin | ||||||||||||
| 4 × MIC | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 3 | 1 | 5 | 5 | 5 |
| 2 × MIC | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 5 | 5 | 5 |
| MIC | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 5 | 5 | 5 |
| 0.5 × MIC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
| Azithromycin | ||||||||||||
| 4 × MIC | 0 | 0 | 0 | 4 | 0 | 0 | 5 | 5 | 3 | 5 | 5 | 5 |
| 2 × MIC | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 5 | 2 | 5 | 5 | 5 |
| MIC | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 5 | 5 | 5 |
| 0.5 × MIC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Clarithromycin | ||||||||||||
| 4 × MIC | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 2 | 1 | 5 | 5 | 4 |
| 2 × MIC | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 5 | 5 | 4 |
| MIC | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5 | 5 | 3 |
| 0.5 × MIC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
| Roxithromycin | ||||||||||||
| 4 × MIC | 0 | 0 | 0 | 2 | 0 | 0 | 4 | 3 | 0 | 5 | 5 | 5 |
| 2 × MIC | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 5 | 5 | 5 |
| MIC | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5 | 4 | 3 |
| 0.5 × MIC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Amoxicillin-clavulanate | ||||||||||||
| 4 × MIC | 4 | 1 | 0 | 5 | 5 | 1 | 5 | 5 | 5 | 5 | 5 | 5 |
| 2 × MIC | 4 | 1 | 0 | 5 | 5 | 1 | 5 | 4 | 3 | 5 | 5 | 5 |
| MIC | 3 | 0 | 0 | 5 | 3 | 0 | 5 | 3 | 1 | 5 | 4 | 1 |
| 0.5 × MIC | 1 | 0 | 0 | 4 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 |
| Cefuroxime | ||||||||||||
| 4 × MIC | 5 | 3 | 0 | 5 | 5 | 3 | 5 | 5 | 3 | 5 | 5 | 5 |
| 2 × MIC | 5 | 3 | 0 | 5 | 5 | 3 | 5 | 4 | 2 | 5 | 5 | 4 |
| MIC | 5 | 1 | 0 | 5 | 4 | 1 | 5 | 2 | 1 | 3 | 0 | 0 |
| 0.5 × MIC | 1 | 1 | 0 | 3 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 |
| Cefixime | ||||||||||||
| 4 × MIC | 3 | 2 | 0 | 4 | 3 | 2 | 5 | 5 | 3 | 5 | 5 | 5 |
| 2 × MIC | 3 | 0 | 0 | 4 | 3 | 1 | 5 | 5 | 2 | 5 | 4 | 2 |
| MIC | 2 | 0 | 0 | 3 | 2 | 0 | 4 | 2 | 0 | 3 | 2 | 0 |
| 0.5 × MIC | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
| Cefpodoxime | ||||||||||||
| 4 × MIC | 5 | 5 | 0 | 5 | 5 | 4 | 5 | 5 | 5 | 5 | 5 | 4 |
| 2 × MIC | 5 | 1 | 0 | 5 | 5 | 2 | 5 | 5 | 3 | 5 | 3 | 2 |
| MIC | 3 | 0 | 0 | 5 | 3 | 1 | 5 | 3 | 1 | 3 | 2 | 1 |
| 0.5 × MIC | 1 | 0 | 0 | 3 | 1 | 1 | 2 | 1 | 0 | 0 | 0 | 0 |
| Cefprozil | ||||||||||||
| 4 × MIC | 5 | 4 | 1 | 5 | 5 | 3 | 5 | 5 | 3 | 5 | 4 | 2 |
| 2 × MIC | 5 | 4 | 0 | 5 | 5 | 3 | 5 | 4 | 2 | 2 | 0 | 0 |
| MIC | 5 | 3 | 0 | 5 | 5 | 3 | 5 | 4 | 0 | 0 | 0 | 0 |
| 0.5 × MIC | 5 | 2 | 0 | 4 | 3 | 2 | 4 | 1 | 0 | 0 | 0 | 0 |
| Ceftriaxone | ||||||||||||
| 4 × MIC | 5 | 1 | 0 | 5 | 5 | 1 | 5 | 5 | 3 | 5 | 4 | 1 |
| 2 × MIC | 4 | 0 | 0 | 5 | 4 | 0 | 5 | 5 | 2 | 5 | 2 | 0 |
| MIC | 4 | 0 | 0 | 5 | 1 | 0 | 5 | 4 | 1 | 2 | 0 | 0 |
| 0.5 × MIC | 0 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 |
a
Amoxicillin was not tested (all strains are β-lactamase positive).
b
ΔLog10 CFU per milliliter lower than at 0 h.