TABLE 4.
MICs and PAEs of five H. influenzae strains
| Drug | MIC range (μg/ml) | PAE (h)a |
|---|---|---|
| ABT-773b | 1.0–8.0 | ≥6.1 (4.9–>8.0) |
| Erythromycinb | 4.0–16.0 | ≥3.8 (0.9–>6.7) |
| Azithromycinb | 2.0–8.0 | ≥6.1 (4.4–>7.4) |
| Clarithromycinb | 4.0–16.0 | ≥3.3 (1.6–>6.7) |
| Roxithromycinb | 8.0–32.0 | ≥3.3 (1.9–>6.7) |
| Amoxicillinb | 0.5–4.0 | 0.5 (0–2.6) |
| Amoxicillin-clavulanateb | 0.5–1.0 | 0.7 (0–3.4) |
| Cefuroximec | 0.5–1.0 | 1.0 (0–5.0) |
| Cefiximec | 0.016–0.125 | 0.7 (0–3.7) |
| Cefpodoximec | 0.125–0.25 | 0.7 (0–3.5) |
| Cefprozild | 4.0–16.0 | 0.7 (0–3.3) |
| Ceftriaxonec | 0.004–0.008 | 0.6 (0–3.2) |
a
Mean (range).
b
Exposure at 4 times MIC for 1 h.
c
Exposure at 10 times MIC for 1 h.
d
Exposure at 2 times MIC for 1 h.