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. 2022 Apr 8;14:867452. doi: 10.3389/fnagi.2022.867452

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Copyright © 2022 Ford, Zhang, Sweeney, Merkler, de Leon, Gupta, Nguyen and Ivanidze.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative T2-FLAIR images (A,D), k_W maps (B,E) and CBF maps (C,F) obtained from a 76-year-old subject with no vascular risk factors and no significant WMH (A–C), and a 74-year-old subject with two vascular risk factors (HTN, HLD) and moderate burden of WMH (D–F). The subject without appreciable WMH demonstrated mean cortical k_W of 98.4 min^–1, mean white matter k_W of 93.8 min^–1, mean cortical CBF of 56.6 mL/100 g/min, and mean white matter CBF of 47.6 mL/100 g/min. The subject with moderate WMH burden (total WMH volume of 5,456 mm³) demonstrated lower mean cortical k_W of 72.6 min^–1, mean white matter k_W of 64.0 min^–1, mean cortical CBF of 28.1 mL/100 g/min, and mean white matter CBF of 23.6 mL/100 g/min.