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. 2022 Apr 8;12:855603. doi: 10.3389/fonc.2022.855603

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Copyright © 2022 Wu, He, Xiong, Shi, Chen, Feng and Wen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combination of BH and gefitinib suppressed the growth of PC-9/GR xenografts tumor. (A) Representative pictures of tumors. n = 6 per group. (B) Tumor volume of PC-9/GR xenografts. (C) Tumor weights and size of PC-9/GR xenografts. (D, E) TUNEL assay and H&E staining were performed to examine histological morphology and apoptosis of tumor tissues, and the scale bar was 100 μm. (F, G) The protein levels of Ki-67 and Notch3 of PC-9/GR xenografts were detected by IHC, and the scale bar was 200 μm. (H) The expressions of Notch3, β-catenin, FOXO3a, p-EGFR (Tyr1068), EGFR, and BPC (Lys1535)/P300 (Lys1499) of PC-9/GR xenografts were measured by Western blot. “*” represents Gef +BH group, BH group, Gef group vs. the group (*p < 0.05, **p < 0.01, ***p< 0.001).