. 2022 Apr 8;12:805613. doi: 10.3389/fonc.2022.805613

Table 4.

Hormonal receptors: comments from the working group.

Comments
- ER and PR are affordable immunohistochemical markers, available in all pathological laboratories worldwide and thus this scoring system could be easily implemented in routine practice. - Scoring for ER and PR adds relevant prognostic information to current clinical practice - Correlation between ER/PR expression in preoperative and postoperative material could be investigated also in EC, as well as already test in breast cancer - Reporting of percentages in the form of continuous or semicontinuous values for ER/PR expression, avoiding dichotomous values (e.g., positive, negative) is recommended - Reporting of intensity score is also advised - Immunohistochemical analysis for ER and PR expression can be performed manually or by digital image analysis that could provide a more objective and reproducible evaluation

Comments

- ER and PR are affordable immunohistochemical markers, available in all pathological laboratories worldwide and thus this scoring system could be easily implemented in routine practice.
- Scoring for ER and PR adds relevant prognostic information to current clinical practice
- Correlation between ER/PR expression in preoperative and postoperative material could be investigated also in EC, as well as already test in breast cancer
- Reporting of percentages in the form of continuous or semicontinuous values for ER/PR expression, avoiding dichotomous values (e.g., positive, negative) is recommended
- Reporting of intensity score is also advised
- Immunohistochemical analysis for ER and PR expression can be performed manually or by digital image analysis that could provide a more objective and reproducible evaluation