Table 1.
Group incidence and severity of dorsal root ganglia microscopic findings in male Wistar Han rats
| Dose (vg/kg) | 0 | 2 × 1013 | 5 × 1013 | 1 × 1014 |
|---|---|---|---|---|
| n per group | 6 | 6 | 6 | 6 |
| Neuron Degeneration/Necrosis | 0 | 0 | 5 | 6 |
| Minimal (Grade 1) | 0 | 0 | 3 | 3 |
| Mild (Grade 2) | 0 | 0 | 2 | 3 |
| Nerve Fiber Degeneration | 1 | 1 | 5 | 6 |
| Minimal (Grade 1) | 1 | 1 | 4 | 0 |
| Mild (Grade 2) | 0 | 0 | 0 | 3 |
| Moderate (Grade 3) | 0 | 0 | 1 | 3 |
| Mononuclear Cell Infiltration | 0 | 0 | 3 | 6 |
| Minimal (Grade 1) | 0 | 0 | 1 | 6 |
| Mild (Grade 2) | 0 | 0 | 2 | 0 |
| Satellite Glial Cell Hypertrophy/Hyperplasia | 0 | 0 | 2 | 6 |
| Minimal (Grade 1) | 0 | 0 | 0 | 3 |
| Mild (Grade 2) | 0 | 0 | 2 | 3 |