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. 2022 Mar 28;25:264–277. doi: 10.1016/j.omtm.2022.03.017

Table 2.

Group incidence and severity of dorsal root ganglia microscopic findings in male cynomolgus monkeys

Dose (vg/dose) 3.0 × 1013 3.3 × 1013 8.7 × 1013
Number of injections 1 3 1
n per group 2 2 2
Neuron degeneration/necrosis 0 1 2
 Minimal (Grade 1) 0 0 0
 Mild (Grade 2) 0 1 1
 Moderate (Grade 3) 0 0 1
Nerve fiber degeneration 0 1 2
 Minimal (Grade 1) 0 1 1
 Mild (Grade 2) 0 0 0
 Moderate (Grade 3) 0 0 1
Mononuclear cell infiltration 2 1 2
 Minimal (Grade 1) 2 0 0
 Mild (Grade 2) 0 1 1
 Moderate (Grade 3) 0 0 1