Figure 2.

TAM-involved tumor immune microenvironment

Various tumor-infiltrating cells, mainly including TAMs (i.e. M0, M1- and M2-like type), NK cells, CD8⁺ cells, γδ T cells, and regulatory T (Treg) (CD4⁺ CD25⁺ Foxp3⁺ Treg) cells, form a niche in the tumor microenvironment. Within the niche, intense communication occurs between macrophages and other immune cells through cell-to-cell contact and/or soluble messengers, resulting in tumor suppression or progression.