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. 2022 Mar 16;25:98–120. doi: 10.1016/j.omto.2022.03.002

Figure 3.

Figure 3

ncRNA functions in tumor progression

miRNAs regulate gene expression by inducing RNA cleavage or degradation or blocking RNA translation. lncRNAs function as molecular signals, decoys, guides, or scaffolds to mediate gene expression by interacting with DNAs, mRNAs, proteins, or other ncRNAs. circRNAs mediate gene expression by acting as miRNA sponges and protein scaffolds. Both of those ncRNAs play important roles in cancer progression, such as tumor transformation, growth, and angiogenesis.