Figure 7.

Results from the in vitro drug release testing: (a) released 5-FU concentration as a function of time: the fluctuating profile at the beginning of the release (at lower times) indicates a multi-layered structure. Each polymer layer acts as a barrier and somewhat retards the 5-FU release. As the latter disintegrates, the concentration rises again; (b) Cumulative released quantity of embedded 5-FU as a function of time: the apparent explanation of the cumulative released quantity is the presence of the incorporated FePt NPs in the second sample, which could be due to the interaction of the NPs with 5-FU, or the influence the particles might have on the incorporated 5-FU in the beginning. In both cases, the release slows down in the later times; (c) The percentage of released 5-FU as a function of time: the percentage between both samples is the same, which confirms the similarity in the releasing mechanisms, despite different compositions. It also confirms that the identical course of pharmacotherapy, despite different incorporated 5-FU dose; (d) schematic depiction of the multilayer structure of the prepared nanofilms.