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. 2022 Apr 11;14(4):840. doi: 10.3390/pharmaceutics14040840

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MRI and PAI performance of CaF₂:Y,Gd,Nd NPs. (a) The VSM measurement of CaF₂:Y,Gd,Nd NPs; (b) MRI signal intensity of different concentrations of CaF₂:Y,Gd,Nd NPs with increasing recovery time; (c) in vitro T1 relaxation rates of different CaF₂:Y,Gd,Nd NP concentrations; inset shows T1-weighted MRI images of CaF₂:Y,Gd,Nd NPs at different concentrations in 0.5 % agarose gel; (d) ex vivo MRI images before and after subcutaneous injection of CaF₂:Y,Gd,Nd NPs (10 mg/mL) into a mouse cadaver; (e) in vitro PA images (2D and 3D) of CaF₂:Y,Gd,Nd NPs (10 mg/mL), water is the control; (f) ex vivo PA images (3D) before and after injection of CaF₂:Y,Gd,Nd NPs (10 mg/mL) into a mouse. Unspecific signal is caused by endogenous tissue chromophores.

MRI and PAI performance of CaF₂:Y,Gd,Nd NPs. (a) The VSM measurement of CaF₂:Y,Gd,Nd NPs; (b) MRI signal intensity of different concentrations of CaF₂:Y,Gd,Nd NPs with increasing recovery time; (c) in vitro T1 relaxation rates of different CaF₂:Y,Gd,Nd NP concentrations; inset shows T1-weighted MRI images of CaF₂:Y,Gd,Nd NPs at different concentrations in 0.5 % agarose gel; (d) ex vivo MRI images before and after subcutaneous injection of CaF₂:Y,Gd,Nd NPs (10 mg/mL) into a mouse cadaver; (e) in vitro PA images (2D and 3D) of CaF₂:Y,Gd,Nd NPs (10 mg/mL), water is the control; (f) ex vivo PA images (3D) before and after injection of CaF₂:Y,Gd,Nd NPs (10 mg/mL) into a mouse. Unspecific signal is caused by endogenous tissue chromophores.