Table 4.
Composition and characteristics of the formulated floating tablets.
| Formulation | Drug (mg) |
Hardness (kg) |
Friability (%) |
Thickness (cm) |
Apparent Density (gm/cm3) |
Lag Time (min) |
MHIB a (kg) |
|---|---|---|---|---|---|---|---|
| F1 | 0.0 | 5.2 ± 0.2 | 0.324 ± 0.01 | 0.563 ± 0.001 | 0.923 ± 0.009 | 0.0 | 10.0 |
| F2 | 50 | 5.4 ± 0.2 | 0.411 ± 0.04 | 0.553 ± 0.004 | 0.939 ± 0.009 | 0.0 | 8.5 |
| F3 | 100 | 5.3 ± 0.1 | 0.495 ± 0.07 | 0.543 ± 0.003 | 0.957 ± 0.010 | 0.0 | 7.0 |
| F4 | 120 | 5.6 ± 0.3 | 0.573 ± 0.04 | 0.536 ± 0.003 | 0.968 ± 0.010 | 0.0 | 6.5 |
| F5 | 150 | 5.3 ± 0.2 | 0.686 ± 0.06 | 0.533 ± 0.002 | 0.974 ± 0.010 | 0.0 | 6.0 |
| F6 | 200 | 5.7 ± 0.3 | 0.833 ± 0.04 | 0.516 ± 0.005 | 0.994 ± 0.010 | 35.0 ± 5.0 | 4.0 |
| F7 | 250 | 5.7 ± 0.2 | 0.864 ± 0.03 | 0.513 ± 0.004 | 1.01 ± 0.011 | 42.7 ± 2.52 | - |
a Maximum hardness of immediate buoyancy.