Table 8.
Metronidazole pharmacokinetic parameters in human volunteers following administration of a single oral dose of 150 mg as floating and conventional tablets a.
| Parameters | Floating Tablets | Conventional Tablets |
|---|---|---|
| Cmax (µg/mL) | 2.490 ± 0.653 | 2.060 ± 0.473 |
| Tmax (h) | 5.66 ± 2.804 b | 2.5 ± 2.756 |
| Ka (h−1) | 0.78 ± 0.319 b | 1.336 ± 0.273 |
| K (h−1) | 0.03 ± 0.003 | 0.070 ± 0.005 |
| T1/2 (h) | 9.52 ± 0.510 | 9.837 ± 0.787 |
| AUC0–24 (µg·h·mL−1) | 34.155 ± 7.099 b | 28.478 ± 6.394 |
| AUC0–∞ (µg·h·mL−1) | 42.658 ± 8.952 b | 35.535 ± 7.664 |
| MRT (h) | 15.917 ± 0.876 b | 14.342 ± 0.541 |
a Data are given as mean ± SD (n = 6). b Significantly different from conventional tablets (p < 0.05). Cmax (µg/mL): maximum serum concentration. Tmax (h): time required to achieve maximum serum concentration. Ka (h−1): absorption rate constant. K (h−1): elimination rate constant. T1/2 (h): elimination half-life. AUC (µg·h·mL−1): area under the curve.